منابع مشابه
Crucial Role of miR-433 in Regulating Cardiac Fibrosis
Dysregulation of microRNAs has been implicated in many cardiovascular diseases including fibrosis. Here we report that miR-433 was consistently elevated in three models of heart disease with prominent cardiac fibrosis, and was enriched in fibroblasts compared to cardiomyocytes. Forced expression of miR-433 in neonatal rat cardiac fibroblasts increased proliferation and their differentiation int...
متن کاملMiR-433 and miR-127 Arise from Independent Overlapping Primary Transcripts Encoded by the miR-433-127 Locus
MicroRNAs play significant roles in development, metabolism and carcinogenesis, however, limited information is available about their primary transcripts and the transcriptional regulation of the microRNA genes. We report here the cloning of two primary miRNAs (pri-miR-433 and pri-miR-127) encoded by the miR-433-127 locus. Using both database mining and experimental methods, we isolated the ful...
متن کاملSearching for miR-acles in cardiac fibrosis.
Tissue fibrosis is a major cause of organ dysfunction in diseases of the cardiovascular, pulmonary, renal, and hepatic systems. Despite a relatively sophisticated understanding of the cell biological processes underlying fibrosis, there are few effective therapies, emphasizing the need for new insights into this disorder. A series of recent articles, including one by Creemers and colleagues in ...
متن کاملCardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes
Diabetic cardiomyopathy is a cascade of complex events leading to eventual failure of the heart and cardiac fibrosis being considered as one of its major causes. miR-133a is one of the most abundantly expressed microRNAs in the heart. We investigated the role of miR-133a during severe hyperglycaemia. And, our aim was to find out what role miR-133a plays during diabetes-induced cardiac fibrosis....
متن کاملmiR-21 and cardiac fibrosis: another brick in the wall?
Organ fibrosis is a common final pathway of long-lasting and iterative tissue fibrosis, and is present in several pathologies, including ischaemicheart disease, diabetesmellitus, hypertension, andchronic kidney disease. Thus, it represents a widespread cause of morbidity and mortality. Tissue fibrosis is characterized by an excessive and uncontrolled deposition of extracellular matrix (ECM) ele...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2016
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2016.11.28